Laboratory of Applied Biochemistry

Acting Head of the Laboratory: Olga V. Gribovskaya

Ph. D. (chemistry)

phone: +375 (17) 3748263

e-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Established in 2001.
Personnel: 13 researches including 1 D.Sc. and 4 Ph.D.

Fundamental and applied research in the fields of bioorganic chemistry, biochemistry and molecular biology of peptide compounds, study of structure and function of low molecular weight bioregulators of peptide nature
Development of methods for chemical synthesis of biologically active peptide compounds, possessing antithrombotic, antiaggregatory, immunobiological activity, etc.
Creating a theoretical basis and software for modeling the structure of proteins and peptides. Quantum chemical modeling of peptide elicitor molecules and their analogs in order to find compounds with elicitor activity
Development and production of hemosorbents for application in efferent medicine.

Development and approbation of new simulation method for protein molecule surface for binding site structure determination. A series of synthesized peptides which were predicted on the basis of computer modeling the binding sites of regulatory proteins (protein A, TNF-alpha receptor, apolipoproteins) proved to have properties of functional analogs of these proteins
Synthesis of tripeptide Arg-Gly-Asp analogs possessing an antiaggregative activity
Synthesis of new caspase substrates and inhibitors which can be used for monitoring and regulation of apoptose
Synthesis of oligopeptide analogs of vasopressin and oxytocine with nootropic and antidepressant activity.
Development, production and introduction into clinical practice of hemosorbents Hemo-Proteazsorb, Anti-IgE-Hemo, LPS-Hemo, Antilipoproteid, Nucleosorb for use in efferent medicine
Creation of an original learning and memory stimulator based on tetra-peptide (in co-operation with RUPE "Belmedpreparaty").

Martinovich V.P., Golubovich V.P., Gribovskaya O.V., Yanchenko V.V., Yanchenko A.V. Synthesis of heptapeptide fragment of a high-affinity FC receptor of immunoglobulin E which binds antibodies of the E class. // Proceed. Nat. Acad. Sci. Bel., Ser. Chem. Sci. (Rus). - 2018, no. 1, P.55-64.
Sokolov, Yu.A. Prediction of the biological activity of compounds using quantum chemical methods. // Minsk, Belaruskaya navuka (Rus). - 2008, 311 p.
Vvedensky D.V., Kirkovsky V.V., Golubovich V.P., Gapanovich V.N., Starostin A.V., Makarevich D.A. Clinical efficacy of biospecific hemosorbent "Liposorb". // Vestnik Rossiiskoi Akademii Med. Nauk (Rus). - 2009, no. 10, P.40-43.
Sokolov Yu.A. Elicitors and their use in crop production. // Minsk, Belaruskaya Navuka (RUS). - 2016, 201 p.